α- and β- Thalassemia StripAssays®

The α- and β-Thalassemia StripAssay® kits provide easy and cost effective solutions for the identification of  the most relevant mutations in the alpha and beta globin genes. In the case of the α-Thalassemia StripAssay®, broad coverage of 21 mutations ensures greater than 90% coverage of known significant mutations. For β-Thalassemia a series of three StripAssay® have been customized to cover regional differences in specific mutations targeting Mediterranean, Indian and Middle Eastern, and South East African populations, respectively.

α-Globin – ß-Globin StripAssay® Product Brochure

• Kits are based on reverse-hybridization of biotinylated PCR products.
• Minimal equipment required (thermal cycler, shaking water bath).
• Technology combines probes for mutations and controls in a parallel array of allele-specific oligonucleotides.
• Functions using immobilized oligos on a teststrip.
• Strips show mutations by enzymatic color reaction visible to the naked eye.
• Proprietary software package (Evaluator™) that aids in data interpretation, storage, and archiving.

Publications

Genetic Modifiers in β-Thalassemia Intermedia: A Study on 102 Iraqi Arab Patients (Al-Allawi 2015)

Characterizing a Cohort of α-Thalassemia Couples Collected During Screening for Hemoglobinopathies: 14 Years of an Iranian Experience (Nejad 2014)

Analyzing 5 ‘ HS3 and 5 ‘ HS4 LCR core regions and NF-E2 in Iranian thalassemia intermedia patients with normal or carrier status for beta-globin mutations (Neishabury 2011)

Vascular at-risk genotypes and disease severity in Lebanese sickle cell disease patients (2010 Farra)

Mutations Detected

α-Globin StripAssay® Catalog 4-160

21 mutations covering > 90 % of relevant mutations

ß-Globin StripAssay® Catalog MED 4-130
ß-Globin StripAssay® Catalog IME 4-140
ß-Globin StripAssay® Catalog SEA 4-150

22 mutations covering > 90 % of relevant mutations (optimized for Mediterranean countries, Middle East and India, Southeast Asia)