Ideal for Liquid Biopsy and Exosomes

Pure•SAL™ was developed for the controlled and standardized collection of RNA or protein biomarkers from oral fluid specimens for subsequent stabilization and analysis in life science and research applications.

The Pure•SAL™ Oral Specimen Collection Kit provides a simple non-invasive and rapid platform for isolating “liquid biopsy” specimens including cell free DNA, cell free RNA, exosomes, or proteins in a single step. The harvested, purified saliva specimen is stabilized if required and available for downstream PCR, genotyping, sequencing, proteomics and other applications, depending upon the desired results.

Principles of the Kit

Pure•SAL™ uses a highly absorbent pad to collect saliva, which also acts to remove a high percentage of mucinous material that can cause interference with downstream assays. The Sample is subsequently purified further by expressing the sample through the compression tube of the device containing a proprietary filtration medium that removes additional interferants and large molecules. The purified sample is then directed into a standard collection tube and is stabilized independently for immediate use or stored for long periods of time pending analysis.


Pure•SAL™ Product Insert

Pure•SAL™ Step by Step Instructions – English

Pure•SAL™ Step by Step Instructions – Spanish


A Paper-Based Colorimetric Molecular Test for SARS-CoV-2 in Saliva. (J. Wang 2021)

Longitudinal Monitoring of EGFR and PIK3CA Mutations by Saliva-Based EFIRM in Advanced NSCLC Patients With Local Ablative Therapy and Osimertinib Treatment: Two Case Reports (Wong D, 2020)

Human Salivary Protein Analysis Using RNA•ProSAL™, Pure•SAL™, and the Passive Drooling Method in a Pakistani Population (Zohaib K. 2016)

A Simplified Method for the Isolation of Exosomes from Saliva using a Prototype Saliva Collection Device (Laughlin M. 2015)

Saliva and biofilm-based diagnostics: a critical review of the literature concerning sialochemistry (Novy B., 2014)

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