Pure•SAL™ was developed for the controlled and standardized collection of RNA or protein biomarkers from oral fluid specimens for subsequent stabilization and analysis in life science and research applications.
The Pure•SAL™ Oral Specimen Collection Kit provides a simple non-invasive and rapid platform for isolating “liquid biopsy” specimens including cell free DNA, cell free RNA, exosomes, or proteins in a single step. The harvested, purified saliva specimen is stabilized if required and available for downstream PCR, genotyping, sequencing, proteomics and other applications, depending upon the desired results.
Pure•SAL™ uses a highly absorbent pad to collect saliva, which also acts to remove a high percentage of mucinous material that can cause interference with downstream assays. The Sample is subsequently purified further by expressing the sample through the compression tube of the device containing a proprietary filtration medium that removes additional interferants and large molecules. The purified sample is then directed into a standard collection tube and is stabilized independently for immediate use or stored for long periods of time pending analysis.
Pure•SAL™ Step by Step Instructions – English
Pure•SAL™ Step by Step Instructions – Spanish
A Paper-Based Colorimetric Molecular Test for SARS-CoV-2 in Saliva. (J. Wang 2021)
Longitudinal Monitoring of EGFR and PIK3CA Mutations by Saliva-Based EFIRM in Advanced NSCLC Patients With Local Ablative Therapy and Osimertinib Treatment: Two Case Reports (Wong D, 2020)
Human Salivary Protein Analysis Using RNA•ProSAL™, Pure•SAL™, and the Passive Drooling Method in a Pakistani Population (Zohaib K. 2016)
A Simplified Method for the Isolation of Exosomes from Saliva using a Prototype Saliva Collection Device (Laughlin M. 2015)
Saliva and biofilm-based diagnostics: a critical review of the literature concerning sialochemistry (Novy B., 2014)