PGX-CYP2D6 StripAssay®

The PGX-CYP2D6 StripAssay® offers the ability to detect common variants with impaired enzyme activity. CYP2D6 is a member of the cytochrome P450 superfamily, and is one of the most important liver enzymes involved in the metabolism of xenobiotics in the body. PGX-CYP2D6 StripAssay® allows patients with defective enzyme variants to avoid severe adverse reactions due to drug accumulation and toxicity.

PGX-CYP2D6 StripAssay® Brochure

  • Kits are based on reverse-hybridization of biotinylated PCR products.
  • Minimal equipment required (thermal cycler, shaking water bath).
  • Technology combines probes for mutations and controls in a parallel array of allele-specific oligonucleotides.
  • Functions using immobilized oligos on a teststrip.
  • Strips show mutations by enzymatic color reaction visible to the naked eye.
  • Proprietary software package (Evaluator™) that aids in data interpretation, storage, and archiving.

cyp2d2 chart

Allelic Variants Detected

PGX-CYP2D6 StripAssay® Catalog 4-760

CYP2D6*3 (2637delA)

CYP2D6*4 (193 G>A)

CYP2D6*6 (1795delT)

 

For Research Use Only [RUO]. Not for use in diagnostic procedures.